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Article

Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic.

The Journal of steroid biochemistry and molecular biology - 1 Jan 2017

Auchus Richard J

Abstract excerpt

Steroid 17-hydroxylase 17,20-lyase (cytochrome P450c17, P450 17A1, CYP17A1) catalyzes two major reactions: steroid 17-hydroxylation followed by the 17,20-lyase reactions. The most severe mutations in the cognate CYP17A1 gene abrogate all activities and cause combined 17-hydroxylase/17,20-lyase deficiency (17OHD), a biochemical phenotype that is replicated by treatment with the potent CYP17A1 inhibitor abiraterone...

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Identifiers

PMID: 26862015
DOI: 10.1016/j.jsbmb.2016.02.002
PMCID: PMC4976049

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POR

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