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Article

The regulation of 17,20 lyase activity.

Steroids - 1 Jan 1997

Miller W L, Auchus R J, Geller D H

Abstract excerpt

P450c17 is a single microsomal enzyme that catalyzes two distinct steroid biosynthetic activities: 17 alpha-hydroxylase and 17,20 lyase. Human beings have only one gene that encodes only one form of P450c17. Three clinical observations indicated that these were independently regulated activities. First, several cases of isolated 17,20 lyase deficiency were reported, in which 17 alpha-hydroxylase activity was...

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Identifiers

PMID: 9029728
DOI: 10.1016/s0039-128x(96)00172-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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The regulation of 17,20 lyase activity.PMID 9029728Read ↗

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The post-translational regulation of 17,20 lyase activity.Semantic proximity Read ↗

The syndrome of 17,20 lyase deficiency.Semantic proximity Read ↗

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A single amino acid substitution in the putative redox partner-binding site of P450c17 as cause of isolated 17,20-lyase deficiency.Semantic proximity Read ↗

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