Article
The regulation of 17,20 lyase activity.
Steroids - 1 Jan 1997
Miller W L, Auchus R J, Geller D H
Abstract excerpt
P450c17 is a single microsomal enzyme that catalyzes two distinct steroid biosynthetic activities: 17 alpha-hydroxylase and 17,20 lyase. Human beings have only one gene that encodes only one form of P450c17. Three clinical observations indicated that these were independently regulated activities....
Topics
- Adrenal Hyperplasia, Congenital
- Amino Acid Sequence
- Animals
- Binding Sites
- Cytochrome P-450 Enzyme System
- Female
- Humans
- Hyperandrogenism
- Male
- Metabolic Diseases
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Phosphorylation
- Protein Conformation
- Puberty
- Sequence Homology, Amino Acid
- Serine