Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.

doi:10.1093/carcin/19.12.2133

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Article

Oltipraz, a novel inhibitor of hepatitis B virus transcription through elevation of p53 protein.

Carcinogenesis - 1 Dec 1998

Chi W J, Doong S L, Lin-Shiau S Y, Boone C W, Kelloff G J, Lin J K

Abstract excerpt

Molecular epidemiological studies of populations at high risk for liver cancer have shown that hepatitis B virus (HBV) and aflatoxin B1 exposures are two major risk factors for this disease. Oltipraz is currently being considered for clinical trial to protect against aflatoxin B1-induced hepatoca...

Topics

Alleles
Antiviral Agents
DNA, Viral
Hepatitis B virus
Humans
Pyrazines
RNA, Viral
Reverse Transcriptase Inhibitors
Thiones
Thiophenes
Transcription, Genetic
Transfection
Tumor Suppressor Protein p53
Virus Integration
Virus Replication

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