Article
Oltipraz chemoprevention trial in Qidong, People's Republic of China: modulation of serum aflatoxin albumin adduct biomarkers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Feb 1998
Kensler T W, He X, Otieno M, Egner P A, Jacobson L P, Chen B, Wang J S, Zhu Y R, Zhang B C, Wang J B, Wu Y, Zhang Q N, Qian G S, Kuang S Y, Fang X, Li Y F, Yu L Y, Prochaska H J, Davidson N E, Gordon G B, Gorman M B, Zarba A, Enger C, Muñoz A, Helzlsouer K J
Abstract excerpt
In 1995, 234 adults from Qidong, People's Republic of China, were enrolled and followed in a Phase IIa 4-methyl-5-(N-2-pyrazinyl)-1,2-dithiole-3-thione (oltipraz) chemoprevention trial. Residents of this area are at high risk for development of hepatocellular carcinoma, in part due to consumption of aflatoxin-contaminated foods. The intervention was a randomized, placebo-controlled, double-blind study. Elements...
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