Article
Evaluation of the role of mitogen-activated protein kinases in the expression of inducible nitric oxide synthase by IFN-gamma and TNF-alpha in mouse macrophages.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jan 1999
Chan E D, Winston B W, Uh S T, Wynes M W, Rose D M, Riches D W
Abstract excerpt
The expression of inducible nitric oxide synthase (iNOS) by macrophages is stimulated by coexposure to IFN-gamma and a number of stimuli, including TNF-alpha. Recent work has shown that TNF-alpha activates members of the mitogen-activated protein kinase family that subsequently trans-activate tra...
Topics
- 3T3 Cells
- Animals
- Calcium-Calmodulin-Dependent Protein Kinases
- Enzyme Activation
- Enzyme Induction
- Gene Expression Regulation
- Interferon-gamma
- JNK Mitogen-Activated Protein Kinases
- MAP Kinase Kinase 4
- MAP Kinase Kinase Kinase 1
- Macrophages
- Mice
- Mice, Inbred C3H