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Article

[Parkinson disease: monogenic forms and genetic susceptibility factors].

Pathologie-biologie - 1 Nov 1998

Brice A

Abstract excerpt

Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. The role of genetic factors in its pathogenesis is supported by several lines of evidence: the high concordance in twins using PET scan; the increased risk among relatives of PD patients in case control and family studies; the existence of monogenic forms of PD. the alpha-synuclein gene is involved in a rare dominant form of the...

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PMID: 9885826

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