Article
Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence.
Alcoholism, clinical and experimental research - 1 Feb 2001
Crabbe J C
Abstract excerpt
Various explanations for the dependence on alcohol are attributed to the development of tolerance to some of alcohol's effects, alterations in sensitivity to its rewarding effects, and unknown pathologic consequences of repeated exposure. All these aspects of dependence have been modeled in laboratory rodents, and these studies have consistently shown a significant influence of genetics. Genetic mapping studies...
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