Article
ETS2 function is required to maintain the transformed state of human prostate cancer cells.
Oncogene - 3 Dec 1998
Sementchenko V I, Schweinfest C W, Papas T S, Watson D K
Abstract excerpt
The contribution of the ETS2 transcription factor to the transformed state in prostate cancer cells has been assessed. Northern blot analysis easily detects ETS2 in DU145 and PC3, high grade human prostate cell lines, but ETS2 is not present in lower grade LNCaP cells. Stable transfection of PC3...
Topics
- Agar
- Androgens
- Blotting, Northern
- Cell Division
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Gene Expression Regulation, Neoplastic
- Genes, Dominant
- Humans
- Male
- Phenotype
- Precipitin Tests
- Prostatic Neoplasms
- Proto-Oncogene Protein c-ets-2
- Proto-Oncogene Proteins
- RNA, Antisense
- Repressor Proteins
- Sequence Deletion