Novel alpha-synuclein-immunoreactive proteins in brain samples from the Contursi kindred, Parkinson's, and Alzheimer's disease.

doi:10.1006/exnr.1998.6975

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Article

Novel alpha-synuclein-immunoreactive proteins in brain samples from the Contursi kindred, Parkinson's, and Alzheimer's disease.

Experimental neurology - 1 Dec 1998

Langston J W, Sastry S, Chan P, Forno L S, Bolin L M, Di Monte D A

Abstract excerpt

A specific mutation (A53T) in the encoding region for alpha-synuclein has been identified in a large multigenerational family with an autosomal dominant parkinsonism known as the Contursi kindred. In this study, we used a monoclonal antibody directed against alpha-synuclein in order to identify n...

Topics

Adult
Aged
Aged, 80 and over
Alzheimer Disease
Antibody Specificity
Blotting, Western
Brain Chemistry
DNA Mutational Analysis
Family Health
Female
Frontal Lobe
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lewy Bodies

Male

Middle Aged

Mutation

Nerve Degeneration

Nerve Tissue Proteins

Source

Open in PubMed

Identifiers

PMID: 9878203
DOI: 10.1006/exnr.1998.6975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9878203-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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