Article
Mutation screening in exons 3 and 4 of alpha-synuclein in sporadic Parkinson's and sporadic and familial dementia with Lewy bodies cases.
Neuroreport - 1 Dec 1998
El-Agnaf O M, Curran M D, Wallace A, Middleton D, Murgatroyd C, Curtis A, Perry R, Jaros E
Abstract excerpt
Recently it has been reported that a missense G(88)C mutation within exon 3 and a missense G(209)A mutation within exon 4 of the alpha-synuclein gene were linked to familial Parkinson's Disease (PD). We decided to investigate if these and any other mutations in exons 3 and 4 of the alpha-synuclei...
Topics
- Dementia
- Exons
- Female
- Genetic Testing
- Humans
- Lewy Bodies
- Male
- Mutation
- Nerve Tissue Proteins
- Parkinson Disease
- Periodicity
- Polymorphism, Single-Stranded Conformational
- Synucleins
- alpha-Synuclein