Article
Low frequency of alpha-synuclein mutations in familial Parkinson's disease.
Annals of neurology - 1 Mar 1998
Farrer M, Wavrant-De Vrieze F, Crook R, Boles L, Perez-Tur J, Hardy J, Johnson W G, Steele J, Maraganore D, Gwinn K, Lynch T
Abstract excerpt
A mutation in exon 4 of the alpha-synuclein (NACP) gene has been reported to explain the chromosome 4 linkage to autosomal dominant Parkinson's disease. We developed primers and methods for exonic sequencing of this gene and sequenced the entire coding region of the gene in 6 families with autosomal dominant disease and in 2 cases of lytico and bodig from Guam. In addition, we have sequenced exon 4 of this gene...
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