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Involvement of extracellular signal-regulated kinase/mitogen-activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line.

World journal of gastroenterology - 1 Dec 2004

Guan Jian, Chen Xiao-Ping, Zhu Hong, Luo Shun-Feng, Cao Bin, Ding Lei

Abstract excerpt

AIM: To investigate the molecular mechanism of the influence of HBx protein on multidrug resistance associated genes: multidrug resistance 1 (MDR-1), multidrug related protein (MRP-1), lung resistance related protein (LRP) in hepatoma cells and the potential role of extracellular signal-regulated kinase/mitogen-activated protein kinase (ERK/MAPK) pathway in this process. METHODS: A cell model stably expressing...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 1
Carcinoma, Hepatocellular
Cell Line, Tumor
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Extracellular Signal-Regulated MAP Kinases
Humans
Liver Neoplasms
MAP Kinase Signaling System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multidrug Resistance-Associated Proteins

Neoplasm Proteins

Phenotype

Transfection

Vault Ribonucleoprotein Particles

Source

Open in PubMed Open full text

Identifiers

PMID: 15526378
DOI: 10.3748/wjg.v10.i23.3522
PMCID: PMC4576240

Genes

LRP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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