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Article

Characterization of tTA and its functional domain in tetracycline repressor-mediated gene repression system.

Archives of pharmacal research - 1 Jun 1998

Kim H J, Kim K H

Abstract excerpt

To elucidate of role(s) of tTA as a repressor in the tTA-mediated gene repression system, we introduced mutations into the acidic domain of VP16 and examined the effects of such various mutations. In the transient repression experiment, a region containing 34 amino acids of the activation domain of VP16 (412-456) which interacts with TFIIB was found to be necessary and sufficient for the tTA-mediated repression...

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Identifiers

PMID: 9875451
DOI: 10.1007/BF02975295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of tTA and its functional domain in tetracycline repressor-mediated gene repression system.PMID 9875451Read ↗

Characterization of the interaction between the acidic activation domain of VP16 and the RNA polymerase II initiation factor TFIIB.Semantic proximity Read ↗

NMR structure of the complex between the Tfb1 subunit of TFIIH and the activation domain of VP16: structural similarities between VP16 and p53.Semantic proximity Read ↗

Critical structural elements of the VP16 transcriptional activation domain.Semantic proximity Read ↗

The C terminus of AvrXa10 can be replaced by the transcriptional activation domain of VP16 from the herpes simplex virus.Semantic proximity Read ↗

Analysis of temperature-sensitive functions of Fos: lack of a correlation between transformation and TRE-dependent trans-activation.Semantic proximity Read ↗

Structure of the VP16 transactivator target in the Mediator.Semantic proximity Read ↗

Mutational analysis of a transcriptional activation region of the VP16 protein of herpes simplex virus.Semantic proximity Read ↗

Transcriptional activation by TFIIB mutants that are severely impaired in interaction with promoter DNA and acidic activation domains.Semantic proximity Read ↗

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