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Article

Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression.

European journal of biochemistry - 1 Dec 1998

Minami T, Tachibana K, Imanishi T, Doi T

Abstract excerpt

In the rat platelet factor 4 (PF4) promoter, Ets motifs and GATA motifs are located at positions -880, -75 and -135, -30, respectively, and their motifs are found in the promoter region of most megakaryocyte protein genes. In order to investigate how the Ets and GATA motifs affect PF4 promoter activity, we constructed Ets and/or GATA motif mutant genes. A single disruption of either -75Ets, -135GATA, or -30GATA...

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Identifiers

PMID: 9874259
DOI: 10.1046/j.1432-1327.1998.2580879.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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