Article
Both Ets-1 and GATA-1 are essential for positive regulation of platelet factor 4 gene expression.
European journal of biochemistry - 1 Dec 1998
Minami T, Tachibana K, Imanishi T, Doi T
Abstract excerpt
In the rat platelet factor 4 (PF4) promoter, Ets motifs and GATA motifs are located at positions -880, -75 and -135, -30, respectively, and their motifs are found in the promoter region of most megakaryocyte protein genes. In order to investigate how the Ets and GATA motifs affect PF4 promoter ac...
Topics
- Base Sequence
- Cell Line
- DNA Footprinting
- DNA-Binding Proteins
- Erythroid-Specific DNA-Binding Factors
- GATA1 Transcription Factor
- Gene Expression Regulation
- Genes, Reporter
- Humans
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Platelet Factor 4
- Promoter Regions, Genetic
- Proto-Oncogene Protein c-ets-1
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-ets
- RNA, Messenger