Article
Substitution-rate variation among sites and the estimation of transition bias.
Molecular biology and evolution - 1 May 1994
Wakeley J
Abstract excerpt
Substitution-rate variation among sites and differences in the probabilities of change among the four nucleotides are conflated in DNA sequence comparisons. When variation in rate exists among sites but is ignored, biases in the rates of change among nucleotides are underestimated. This paper provides a quantification of this effect when the observed proportions of transitions, P, and transversions, Q, between...
Topics
- Biological Evolution
- DNA, Mitochondrial
- Genetic Variation
- Humans
- Models, Genetic
- Mutation
- Sequence Analysis, DNA