Substitution-rate variation among sites and the estimation of transition bias.

Abstract excerpt

Substitution-rate variation among sites and differences in the probabilities of change among the four nucleotides are conflated in DNA sequence comparisons. When variation in rate exists among sites but is ignored, biases in the rates of change among nucleotides are underestimated. This paper provides a quantification of this effect when the observed proportions of transitions, P, and transversions, Q, between...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biological Evolution
• Share to DNA, Mitochondrial
• Share to Genetic Variation