Article
D2 dopamine receptor and GABA(A) receptor beta3 subunit genes and alcoholism.
Psychiatry research - 16 Nov 1998
Noble E P, Zhang X, Ritchie T, Lawford B R, Grosser S C, Young R M, Sparkes R S
Abstract excerpt
As the dopaminergic and GABAergic systems have been implicated in alcohol-related behaviors, variants of the D2 dopamine receptor (DRD2) and GABA(A) receptor beta3 subunit (GABRB3) genes were determined in a population-based association study of Caucasian non-alcoholic and alcoholic subjects. In severe alcoholics, compared to non-alcoholics, a significant increase was found in the prevalence (P = 1.7 x 10(-5))...
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