Article
Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation.
The Journal of biological chemistry - 25 Dec 1998
Raffioni S, Zhu Y Z, Bradshaw R A, Thompson L M
Abstract excerpt
The effect of six point mutations causing various human skeletal dysplasias, occurring in the transmembrane (TM) and kinase domains (KD) of fibroblast growth factor receptor 3, were introduced into a chimera composed of the extracellular domain of human platelet-derived growth factor beta and the...
Topics
- Adaptor Proteins, Signal Transducing
- Animals
- Cell Differentiation
- GRB2 Adaptor Protein
- Humans
- Isoenzymes
- Membrane Proteins
- Models, Biological
- Mutation
- Neurites
- Osteochondrodysplasias
- PC12 Cells
- Phospholipase C gamma
- Phosphoproteins
- Phosphorylation
- Platelet-Derived Growth Factor
- Protein Binding
- Protein-Tyrosine Kinases