Optimizing drug therapy based on genetic differences: implications for the clinical setting.

doi:10.1097/00044067-199811000-00005

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Article

Optimizing drug therapy based on genetic differences: implications for the clinical setting.

AACN clinical issues - 1 Nov 1998

Prows D R, Prows C A

Abstract excerpt

Differences in drug responses due to gene alterations are rapidly being identified. Gene alterations may inhibit the function of an enzyme so that an active drug accumulates, causing adverse reactions with normal doses. Alternatively, gene alterations may accelerate enzymatic function so that an...

Topics

Critical Care
Drug Therapy
Drug-Related Side Effects and Adverse Reactions
Education, Nursing, Continuing
Genetic Testing
Genetic Variation
Genotype
Humans
Mutation
Patient Selection
Pharmaceutical Preparations
Polymorphism, Genetic

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