Article
Genetic testing for pharmacogenetics and its clinical application in drug therapy.
Clinica chimica acta; international journal of clinical chemistry - 1 Jan 2006
Hiratsuka Masahiro, Sasaki Takamitsu, Mizugaki Michinao
Abstract excerpt
There is wide individual variation in drug responses and adverse effects. As the main causes of the variation in drug responses, attention has focused on the genetic polymorphisms that encode metabolic enzymes regulating pharmacodynamics and receptors modulating the affinity with the responsive sites. Tailor-made drug therapy analyzes genetic polymorphisms involved in drug responses before drug administration and...
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