Article
Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy.
Neurology - 1 Dec 1998
Wilson M H, Puranam R S, Ottman R, Gilliam C, Limbird L E, George A L, McNamara J O
Abstract excerpt
An autosomal dominant form of human temporal lobe epilepsy (TLE) has been mapped to a region of chromosome 10q that contains the intronless alpha(2A)-adrenergic receptor (alpha(2A)AR) gene. Because mutation of the alpha(2A)AR gene in the mouse fosters epileptogenesis, we developed methods for ana...
Topics
- Animals
- Brain Chemistry
- Chromosomes, Human, Pair 10
- DNA Primers
- Epilepsy, Temporal Lobe
- Genes, Dominant
- Humans
- Mice
- Mutation
- Receptors, Adrenergic, alpha-2