Article
Voltage-activated sodium currents in a cell line expressing a Cu,Zn superoxide dismutase typical of familial ALS.
Neuroreport - 26 Oct 1998
Zona C, Ferri A, Gabbianelli R, Mercuri N B, Bernardi G, Rotilio G, Carri M T
Abstract excerpt
The whole-cell configuration of the patch-clamp recording was used to study the voltage-dependent Na+ currents in a model system for the familial form of amyotrophic lateral sclerosis (ALS) associated with mutations in Cu,Zn superoxide dismutase. Here we report that the amplitude of voltage-gated...
Topics
- 4-Aminopyridine
- Amyotrophic Lateral Sclerosis
- Cadmium
- Calcium
- Electric Stimulation
- Humans
- Ion Channel Gating
- Mutation
- Nerve Degeneration
- Neuroblastoma
- Neurons
- Oxidative Stress
- Patch-Clamp Techniques
- Potassium
- Sodium
- Sodium Channels
- Superoxide Dismutase
- Tumor Cells, Cultured