Article
Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children.
Kidney international - 1 Dec 1998
Xu H, Iijima K, Shiozawa S, Tanaka S S, Inoue Y, Shirakawa T, Nishiyama K, Miwa M, Nakamura H, Yoshikawa N
Abstract excerpt
BACKGROUND: Platelet-activating factor (PAF) may be involved in the pathogenesis of steroid-responsive nephrotic syndrome (SRNS). PAF is degraded to inactive products by PAF acetylhydrolase. We have investigated whether PAF acetylhydrolase gene mutation is involved in SRNS in Japanese children. M...
Topics
- 1-Alkyl-2-acetylglycerophosphocholine Esterase
- Adolescent
- Alleles
- Child
- Female
- Gene Frequency
- Genotype
- Heterozygote
- Homozygote
- Humans
- Incidence
- Japan
- Male
- Mutation
- Nephrotic Syndrome
- Phospholipases A
- Point Mutation
- Polymerase Chain Reaction