Article
Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children.
Kidney international - 1 Dec 1998
Xu H, Iijima K, Shiozawa S, Tanaka S S, Inoue Y, Shirakawa T, Nishiyama K, Miwa M, Nakamura H, Yoshikawa N
Abstract excerpt
BACKGROUND: Platelet-activating factor (PAF) may be involved in the pathogenesis of steroid-responsive nephrotic syndrome (SRNS). PAF is degraded to inactive products by PAF acetylhydrolase. We have investigated whether PAF acetylhydrolase gene mutation is involved in SRNS in Japanese children. METHODS: We identified a point mutation in the PAF acetylhydrolase gene (G994T) using the polymerase chain reaction in...
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