Article
Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy.
American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Aug 1999
Tanaka R, Iijima K, Xu H, Inoue Y, Murakami R, Shirakawa T, Nishiyama K, Miwa M, Shiozawa S, Nakamura H, Yoshikawa N
Abstract excerpt
Platelet-activating factor (PAF) is a potent mediator of inflammatory injury in renal diseases. PAF is degraded to inactive products by PAF acetylhydrolase. Recently, a point mutation (G to T transversion) of the PAF acetylhydrolase gene was observed at position 994, and this mutation was found t...
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