Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy.

American journal of kidney diseases : the official journal of the National Kidney Foundation - 1 Aug 1999

Tanaka R, Iijima K, Xu H, Inoue Y, Murakami R, Shirakawa T, Nishiyama K, Miwa M, Shiozawa S, Nakamura H, Yoshikawa N

Abstract excerpt

Platelet-activating factor (PAF) is a potent mediator of inflammatory injury in renal diseases. PAF is degraded to inactive products by PAF acetylhydrolase. Recently, a point mutation (G to T transversion) of the PAF acetylhydrolase gene was observed at position 994, and this mutation was found to contribute to the variability in plasma PAF levels, with undetectable plasma PAF acetylhydrolase activity occurring...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 1-Alkyl-2-acetylglycerophosphocholine Esterase
Share to Child

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Frequency

Share to Glomerulonephritis, IGA

Share to Peptidyl-Dipeptidase A

Share to Phospholipases A

Share to Point Mutation

Source

Identifiers

PMID: 10430976
DOI: 10.1016/s0272-6386(99)70357-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy.PMID 10430976Read ↗

Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome.Semantic proximity Read ↗

Platelet-activating factor acetylhydrolase gene mutation in Japanese nephrotic children.Semantic proximity Read ↗

Deregulated platelet-activating factor levels and acetylhydrolase activity in patients with idiopathic IgA nephropathy.Semantic proximity Read ↗

Platelet-activating factor acetylhydrolase deficiency. A missense mutation near the active site of an anti-inflammatory phospholipase.Semantic proximity Read ↗

Deficiency of platelet-activating factor acetylhydrolase is a severity factor for asthma.Semantic proximity Read ↗

Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma.Semantic proximity Read ↗

Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese.Semantic proximity Read ↗

Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients.Semantic proximity Read ↗

Platelet-activating factor acetylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis.Semantic proximity Read ↗

Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasma.Semantic proximity Read ↗

Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japan.Semantic proximity Read ↗

[Association between platelet-activating factor acetylhydrolase gene polymorphisms and gastrointestinal bleeding in children with Henoch-Schönlein purpura].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.