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Article

Phenotypic effect correlating with loss of a novel tumor suppressor gene: towards cloning by complementation.

Leukemia - 1 Dec 1998

Cook W D, Alexander B J

Abstract excerpt

We intend to use a gene complementation approach to clone a tumor suppressor gene on mouse chromosome 2, the loss of which contributes to myeloid leukemia. An in vitro model system has been generated using a clonal cell line, in which tumorigenic chromosomal lesions have been selected along with...

Topics

Animals
Biological Assay
Gene Deletion
Genes, Tumor Suppressor
Genetic Complementation Test
Leukemia, Myeloid
Leukemia, Radiation-Induced
Lipopolysaccharides
Mice
Mice, Inbred BALB C
Nitric Oxide Synthase
Nitric Oxide Synthase Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phenotype

Tumor Cells, Cultured

Tumor Necrosis Factor-alpha

Source

Identifiers

PMID: 9844923
DOI: 10.1038/sj.leu.2401212

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9844923-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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