Article
A new animal model for relapsing polychondritis, induced by cartilage matrix protein (matrilin-1).
The Journal of clinical investigation - 1 Sept 1999
Hansson A S, Heinegård D, Holmdahl R
Abstract excerpt
Relapsing polychondritis (RP) differs from rheumatoid arthritis (RA) in that primarily cartilage outside diarthrodial joints is affected. The disease usually involves trachea, nose, and outer ears. To investigate whether the tissue distribution of RP may be explained by a specific immune response, we immunized rats with cartilage matrix protein (matrilin-1), a protein predominantly expressed in tracheal...
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