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Article

Isolation and characterization of iron-independent positive dominant mutants of the diphtheria toxin repressor DtxR.

Proceedings of the National Academy of Sciences of the United States of America - 8 Dec 1998

Sun L, vanderSpek J, Murphy J R

Abstract excerpt

It is well known that the functional activity of the diphtheria toxin repressor DtxR is controlled by iron, which serves as an essential cofactor necessary for activation of target DNA binding by this regulatory element. In this communication, we describe the isolation and characterization of a unique series of DtxR mutants that are constitutively active and repress the expression of beta-galactosidase from a...

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Identifiers

PMID: 9844002
DOI: 10.1073/pnas.95.25.14985
PMCID: PMC24562

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