Characterization of mutations that inactivate the diphtheria toxin repressor gene (dtxR).

doi:10.1128/iai.62.5.1600-1608.1994

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Article

Characterization of mutations that inactivate the diphtheria toxin repressor gene (dtxR).

Infection and immunity - 1 May 1994

Wang Z, Schmitt M P, Holmes R K

Abstract excerpt

The diphtheria toxin repressor (DtxR) is an iron-dependent regulator of diphtheria toxin production and iron uptake in Corynebacterium diphtheriae. It is activated in vitro by divalent metal ions including Fe2+, Cd2+, Co2+, Mn2+, Ni2+, and Zn2+. We characterized 20 different mutations in dtxR ind...

Topics

Alleles
Amino Acid Sequence
Bacterial Proteins
Base Sequence
Blotting, Western
DNA
DNA-Binding Proteins
Molecular Sequence Data
Mutation
Nickel

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