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Article

Purification and characterization of the diphtheria toxin repressor.

Proceedings of the National Academy of Sciences of the United States of America - 15 Aug 1992

Schmitt M P, Twiddy E M, Holmes R K

Abstract excerpt

The diphtheria toxin repressor gene (dtxR) encodes a protein (DtxR) that regulates transcription of the diphtheria toxin gene (tox) by an iron-dependent mechanism. Cloned dtxR was expressed in Escherichia coli from the phage T7 gene 10 promoter, and DtxR was purified. Specific binding of DtxR to the tox+ operator was dependent on reduction of DtxR and the presence of ferrous ions. DtxR protected a sequence of...

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Identifiers

PMID: 1502169
DOI: 10.1073/pnas.89.16.7576
PMCID: PMC49753

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Purification and characterization of the diphtheria toxin repressor.PMID 1502169Read ↗

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