Article
Role of the N-terminal helix in the metal ion-induced activation of the diphtheria toxin repressor DtxR.
Biochemistry - 23 Oct 2007
D'Aquino J Alejandro, Lattimer Judith R, Denninger Andrew, D'Aquino Katharine E, Ringe Dagmar
Abstract excerpt
The metal ion-regulated transcriptional repressor DtxR has been shown to repress the transcription of the diphtheria toxin and other genes associated with ferrous ion homeostasis in Corynebacterium diphtheriae. In vivo studies of single-alanine mutations located in the N-terminal helix of DtxR show that the activity of the mutants is reduced compared to that of the wild type. The three-dimensional structures of...
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