Article
Expression and alteration of p53 and p21(waf1/cip1) influence the sensitivity of chemoradiation therapy for esophageal cancer.
Hepato-gastroenterology - 1 Jan 2000
Shimoyama S, Konishi T, Kawahara M, Aoki F, Harada N, Shimizu S, Murakami T, Kaminishi M
Abstract excerpt
BACKGROUND/AIMS: In vitro analyses have been demonstrated that wild type p53 and p21(waf1/cip1) proteins regulate cellular proliferation and sensitivity of anticancer agents, however, the roles of p53 and p21(waf1/cip1) expression on the response to the chemoradiation therapy for human esophageal...
Topics
- Antineoplastic Combined Chemotherapy Protocols
- Carcinoma, Squamous Cell
- Cisplatin
- Combined Modality Therapy
- Cyclin-Dependent Kinase Inhibitor p21
- Cyclins
- Drug Resistance, Neoplasm
- Esophageal Neoplasms
- Fluorouracil
- Gene Expression
- Humans
- Immunohistochemistry
- Phenotype
- Radiation Tolerance
- Radiotherapy Dosage
- Tumor Suppressor Protein p53