Article
A new BRCA1 mutation in a Filipino woman with a family history of breast and ovarian cancer.
Diagnostic molecular pathology : the American journal of surgical pathology, part B - 1 Jun 1998
Worsham M J, Nathanson S D, Pals G, Christopherson P, Strunk M, Wolman S R
Abstract excerpt
Mutation of the BRCA1 gene in well-defined breast cancer families has been associated with an 87% lifetime risk for breast cancer and a 44% risk for ovarian cancer. Recent data indicate that the risk associated with these mutations is considerably lower, although still far greater than the risk f...
Topics
- Adult
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- DNA Primers
- DNA, Neoplasm
- Female
- Fibroadenoma
- Genes, BRCA1
- Genetic Predisposition to Disease
- Humans
- Michigan
- Ovarian Neoplasms
- Pedigree
- Philippines
- Point Mutation
- RNA, Neoplasm