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[Rapid detection of BRCA-1 germline mutations by the protein truncation test in Tunisian families].

La Tunisie medicale - 1 Sept 2002

Monastiri Kamel, Ben Ahmed Slim, Presneau Nadége, Bignon Jean Yves, Chouchane Lotfi

Abstract excerpt

UNLABELLED: Early-onset breast cancer characterize genetic predisposition to cancer in women. BRCA-1 gene was identified as one of the predisposition genes of breast/ovarian cancer. About 90% of the reported mutations in the hereditary breast and ovarian cancer gene, BRCA-1, result in truncated proteins. The aim of our study is to detect rapidly BRCA-1 mutations by the protein truncation test (PTT) in Tunisian...

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Identifiers

PMID: 12632763

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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