Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutation detection in the breast cancer gene BRCA1 using the protein truncation test.

Molecular biotechnology - 1 Feb 2000

Moore W, Bogdarina I, Patel U A, Perry M, Crane-Robinson C

Abstract excerpt

About 400 distinct mutations have been defined in the BRCA1 gene, and these are spread fairly evenly through the 5592 bp of coding DNA. This circumstance presents a formidable challenge for mutation screening. Apart from total direct sequencing, the preferred screening method has been single-strand conformation polymorphism (SSCP) gels, with a smaller input from constant denaturant gradient electrophoresis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Base Sequence
Share to Cohort Studies
Share to DNA Primers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, BRCA1

Share to Polymorphism, Single-Stranded Conformational

Share to Protein Biosynthesis

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 10872502
DOI: 10.1385/MB:14:2:89

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation detection in the breast cancer gene BRCA1 using the protein truncation test.PMID 10872502Read ↗

Rapid detection of BRCA1 mutations by the protein truncation test.Semantic proximity Read ↗

A complete protein truncation test for BRCA1 and BRCA2.Semantic proximity Read ↗

Screening for mutations in exon 11 of the BRCA1 gene in 70 Italian breast and ovarian cancer patients by protein truncation test.Semantic proximity Read ↗

The protein truncation test: A review.Semantic proximity Read ↗

Ovarian cancer BRCA1 mutation detection: Protein truncation test (PTT) outperforms single strand conformation polymorphism analysis (SSCP).Semantic proximity Read ↗

Detection of BRCA1 mutations in women with early-onset ovarian cancer by use of the protein truncation test.Semantic proximity Read ↗

Comparison of DNA- and RNA-based methods for detection of truncating BRCA1 mutations.Semantic proximity Read ↗

Protein truncation test (PTT) for rapid detection of translation-terminating mutationsSemantic proximity Read ↗

An ELISA-based high throughput protein truncation test for inherited breast cancer.Semantic proximity Read ↗

Identification of seven new BRCA1 germline mutations in Italian breast and breast/ovarian cancer families.Semantic proximity Read ↗

A fluorescent multiplex-DGGE screening test for mutations in the BRCA1 gene.Semantic proximity Read ↗

BRCA1 genomic deletions are major founder mutations in Dutch breast cancer patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.