Low incidence of BRCA1 mutations among Italian families with breast and ovarian cancer.

doi:10.1002/(sici)1097-0215(19981123)78:5<581::aid-ijc9>3.0.co;2-g

Article

Low incidence of BRCA1 mutations among Italian families with breast and ovarian cancer.

International journal of cancer - 23 Nov 1998

Santarosa M, Viel A, Dolcetti R, Crivellari D, Magri M D, Pizzichetta M A, Tibiletti M G, Gallo A, Tumolo S, Del Tin L, Boiocchi M

Abstract excerpt

Most familial breast or ovarian cancers are thought to be due to highly penetrant mutations in the predisposing genes BRCA1 and BRCA2. The cloning of these genes has opened a new era for the genetic counseling of women with a family history of breast or ovarian cancer. To estimate the incidence o...

Topics

Adult
Breast Neoplasms
Female
Genes, BRCA1
Humans
Italy
Middle Aged
Mutation
Ovarian Neoplasms
Polymorphism, Single-Stranded Conformational

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