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Article

Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression.

1 Dec 1998

Abstract excerpt

Cellular expression of the beta2-adrenergic receptor (beta2AR) is controlled in part by a 19-amino acid peptide that regulates mRNA translation. This peptide is encoded by a short open reading frame, termed the 5' leader cistron (5'LC), which is 102 bp upstream of the beta2AR coding block. In 176 normal subjects we found a single nucleotide polymorphism resulting in either Arg (previously denoted wild-type) or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 9835617
DOI: 10.1172/jci4862

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