Article
In vitro repression of Brca1-associated RING domain gene, Bard1, induces phenotypic changes in mammary epithelial cells.
The Journal of cell biology - 30 Nov 1998
Irminger-Finger I, Soriano J V, Vaudan G, Montesano R, Sappino A P
Abstract excerpt
BRCA1-associated RING domain (BARD1) was identified as a protein interacting with the breast cancer gene product BRCA1. The identification of tumorigenic missense mutations within BRCA1 that impair the formation of BARD1-BRCA1 complexes, and of BARD1 mutations in breast carcinomas, sustain the vi...
Topics
- Animals
- Base Sequence
- Breast Neoplasms
- Carrier Proteins
- Cloning, Molecular
- Contact Inhibition
- DNA, Complementary
- Female
- Gene Expression Regulation, Developmental
- Genes, Tumor Suppressor
- Humans
- Mammary Glands, Animal
- Mammary Neoplasms, Experimental
- Mice
- Phenotype
- Precancerous Conditions
- S Phase
- Tumor Suppressor Proteins