Article
RAD1, a human structural homolog of the Schizosaccharomyces pombe RAD1 cell cycle checkpoint gene.
Genomics - 1 Dec 1998
Marathi U K, Dahlen M, Sunnerhagen P, Romero A V, Ramagli L S, Siciliano M J, Li L, Legerski R J
Abstract excerpt
Cell cycle checkpoints are gating mechanisms that govern cell cycle progression in the presence of DNA damage and incomplete DNA replication. The Schizosaccharomyces pombe Rad1 protein is an essential component of cell cycle checkpoints activated by both types of genomic stress. In this study, we report the isolation of a human homolog of the S. pombe RAD1 gene. The hRAD1 protein is also similar to the...
Topics
- Amino Acid Sequence
- Cell Cycle
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Cloning, Molecular
- DNA Damage
- DNA Repair Enzymes
- DNA Replication
- DNA-Binding Proteins
- Endonucleases
- Fungal Proteins
- Genetic Complementation Test
- HeLa Cells