Article
Analysis of mutations at the DNA repair genes in acute childhood leukaemia.
British journal of haematology - 1 Nov 1998
Lin Y W, Kubota M, Koishi S, Sawada M, Usami I, Watanabe K, Akiyama Y
Abstract excerpt
Deficiency in DNA repair capability is considered to be responsible for oncogenesis. Hereditary and sporadic cancers in various tissues have been reported to have mutations at the DNA repair genes. In this study we analysed two excision repair genes (ERCC1 and XPCC) and two mismatch repair genes (hMSH2 and hMTH1) in the leukaemic blasts of newly diagnosed paediatric patients by use of reverse transcriptase...
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