Analysis of mutations at the DNA repair genes in acute childhood leukaemia.

doi:10.1046/j.1365-2141.1998.00973.x

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Article

Analysis of mutations at the DNA repair genes in acute childhood leukaemia.

British journal of haematology - 1 Nov 1998

Lin Y W, Kubota M, Koishi S, Sawada M, Usami I, Watanabe K, Akiyama Y

Abstract excerpt

Deficiency in DNA repair capability is considered to be responsible for oncogenesis. Hereditary and sporadic cancers in various tissues have been reported to have mutations at the DNA repair genes. In this study we analysed two excision repair genes (ERCC1 and XPCC) and two mismatch repair genes...

Topics

Acute Disease
Adolescent
Blotting, Western
Child
Child, Preschool
DNA Repair
DNA, Neoplasm
DNA-Binding Proteins
Endonucleases
Female
Humans
Leukemia
Male
Mutation
Neoplasm Proteins
Proteins
Reverse Transcriptase Polymerase Chain Reaction

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