Article
Assessment of mismatch repair function in leukaemic cell lines and blasts from children with acute lymphoblastic leukaemia
1 Jan 2003
Abstract excerpt
Defects in the DNA mismatch repair (MMR) pathway have recently been shown to be associated with resistance to several of the cytotoxic drugs used in the treatment of children with acute lymphoblastic leukaemia (ALL). We have assessed the MMR status of a range of leukaemic cell lines using an in vitro repair assay and correlated this with protein expression of the best characterized components of the system. We...
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