Article
Wild-type egr1/Krox24 promotes and dominant-negative mutants inhibit, pluripotent differentiation of p19 embryonal carcinoma cells.
Oncogene - 12 Nov 1998
Lanoix J, Mullick A, He Y, Bravo R, Skup D
Abstract excerpt
The zinc-finger transcription factor Krox24 was analysed for its role in differentiation in P19 embryonal carcinoma cells. Reciprocal dominant negative mutants consisting of Krox24 deleted for a crucial region of the zinc-finger domain (delta Krox24) or of the zinc-finger region alone (delta Krox...
Topics
- Amino Acid Substitution
- Animals
- Carcinoma, Embryonal
- Cell Differentiation
- DNA-Binding Proteins
- Early Growth Response Protein 1
- Immediate-Early Proteins
- Mice
- Mutation
- Neoplasm Proteins
- Phenotype
- Recombinant Fusion Proteins
- Sequence Deletion
- Teratocarcinoma
- Transcription Factors
- Transfection
- Tretinoin
- Tumor Cells, Cultured