Article
Integrin laminin receptor profile of pulmonary squamous cell and adenocarcinomas.
Human pathology - 1 Nov 1998
Patriarca C, Alfano R M, Sonnenberg A, Graziani D, Cassani B, de Melker A, Colombo P, Languino L R, Fornaro M, Warren W H, Coggi G, Gould V E
Abstract excerpt
The differential expression of laminin receptors has been shown to modulate the invasive capability of malignant cells. We have investigated the reactivity of human pulmonary squamous carcinomas (SSC, n = 20) and adenocarcinomas (ADC, n = 20) with monoclonal antibodies to the cytoplasmic and extracellular domains of the integrin subunits alpha3 and alpha6. Integrins containing these subunits are laminin...
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