Article
Unusually high frequency of a 69-bp deletion within the carboxy terminus of the LMP-1 oncogene of Epstein-Barr virus detected in Burkitt's lymphoma of Turkish children.
Leukemia - 1 Nov 1998
Tacyildiz N, Cavdar A O, Ertem U, Oksal A, Kutluay L, Uluoglu O, Lin J C
Abstract excerpt
Burkitt's lymphoma (BL) in Turkish children is commonly associated with Epstein-Barr virus (EBV) infection. The C-terminus of the latent membrane protein 1 (LMP-1) of EBV is essential for transformation and the 30-bp deletion detected in this region has been implicated to be associated with a mor...
Topics
- Amino Acid Sequence
- Base Sequence
- Burkitt Lymphoma
- Child
- DNA, Viral
- Genotype
- Herpesvirus 4, Human
- Humans
- Molecular Sequence Data
- Oncogene Proteins, Viral
- Polymerase Chain Reaction
- Sequence Deletion
- Turkey
- Viral Matrix Proteins