Article
High frequency of latent membrane protein-1 30-bp deletion variant with specific single mutations in Epstein-Barr virus-associated nasopharyngeal carcinoma in Moroccan patients.
International journal of cancer - 15 Apr 2006
Dardari Rkia, Khyatti Meriem, Cordeiro Paulo, Odda Mohieddine, ElGueddari Brahim, Hassar Mohammad, Menezes José
Abstract excerpt
Latent membrane protein 1 (LMP-1) is an Epstein-Barr virus-encoded oncoprotein expressed in approximately 50-70% of nasopharyngeal carcinoma (NPC). Previous studies have shown that NPC-derived LMP-1 variants carrying 30 bp deletion and specific mutations in the 3'C-terminal region confer high oncogenic potential and a weak immunogenicity. Although numerous polymorphism studies of LMP-1 have been carried out so...
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