Article
Mutational events in LMP1 gene of Epstein-Barr virus in salivary gland lymphoepithelial carcinomas.
International journal of cancer - 10 Jul 2003
Jen Kai Yu, Cheng Jun, Li Jian, Wu Lanyan, Li Yingfang, Yu Shifeng, Lin Hanliang, Chen Zhilong, Gurtsevitch Vladimir, Saku Takashi
Abstract excerpt
It is still unknown what kinds of roles Epstein-Barr virus (EBV) infection that are highly specific to salivary gland lymphoepithelial carcinomas (LECs) play in their tumorigenesis. To clarify the significance of EBV in LECs, we paid particular attention to the LMP1 gene, which is responsible for triggering several pathways for activating transcription factors. Sixty-one cases of EBV positive LECs confirmed by...
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