Treatment of resting zone chondrocytes with transforming growth factor-beta 1 induces differentiation into a phenotype characteristic of growth zone chondrocytes by downregulating responsiveness to 24,25-(OH)2D3 and upregulating responsiveness to 1,25-(OH)2D3.

doi:10.1016/s8756-3282(98)00132-x

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Article

Treatment of resting zone chondrocytes with transforming growth factor-beta 1 induces differentiation into a phenotype characteristic of growth zone chondrocytes by downregulating responsiveness to 24,25-(OH)2D3 and upregulating responsiveness to 1,25-(OH)2D3.

Bone - 1 Nov 1998

Schwartz Z, Sylvia V L, Liu Y, Dean D D, Boyan B D

Abstract excerpt

To determine if transforming growth factor-beta 1 (TGF-beta 1) can induce the differentiation of resting zone (RC) chondrocytes, confluent, fourth passage cultures of these cells were pretreated for 24, 36, 48, 72, and 120 h with TGF-beta 1. At the end of pretreatment, the media were replaced wit...

Topics

24,25-Dihydroxyvitamin D 3
Alkaline Phosphatase
Animals
Calcitriol
Cell Differentiation
Cells, Cultured
Chondrocytes
Collagen
Dose-Response Relationship, Drug
Down-Regulation
Drug Synergism
Phenotype
Rats
Rats, Sprague-Dawley

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Transforming Growth Factor beta

Up-Regulation

Source

Open in PubMed

Identifiers

PMID: 9823454
DOI: 10.1016/s8756-3282(98)00132-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9823454-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.