Article
The alloreactive T cell response against the class Ib molecule H2-M3 is specific for high affinity peptides.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1998
Dabhi V M, Hovik R, Van Kaer L, Lindahl K F
Abstract excerpt
MHC class Ib molecule H2-M3 presents N-formylated peptides to CD8+ CTLs. Endogenous formylated peptides can come from the N-terminus of each of the 13 proteins encoded by the mitochondrial genome. In peptide competition assays, two of these peptides bind with high affinity, six bind with intermediate affinity, three bind with low affinity, and two do not bind measurably. Alloreactive CTLs from M3-specific, mixed...
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