Article
The alloreactive T cell response against the class Ib molecule H2-M3 is specific for high affinity peptides.
Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 1998
Dabhi V M, Hovik R, Van Kaer L, Lindahl K F
Abstract excerpt
MHC class Ib molecule H2-M3 presents N-formylated peptides to CD8+ CTLs. Endogenous formylated peptides can come from the N-terminus of each of the 13 proteins encoded by the mitochondrial genome. In peptide competition assays, two of these peptides bind with high affinity, six bind with intermed...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 2
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Alleles
- Animals
- Cell Line
- Chloramphenicol
- Clone Cells
- Cytotoxicity, Immunologic
- Epitopes, T-Lymphocyte
- Histocompatibility Antigens Class I
- Isoantigens
- Lymphocyte Culture Test, Mixed
- Mice
- Mice, Inbred BALB C
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred NZB