Article
T cell activity correlates with oligomeric peptide-major histocompatibility complex binding on T cell surface.
The Journal of biological chemistry - 14 Dec 2001
Buslepp J, Zhao R, Donnini D, Loftus D, Saad M, Appella E, Collins E J
Abstract excerpt
Recognition of virally infected cells by CD8+ T cells requires differentiation between self and nonself peptide-class I major histocompatibility complexes (pMHC). Recognition of foreign pMHC by host T cells is a major factor in the rejection of transplanted organs from the same species (allotransplant) or different species (xenotransplant). AHIII12.2 is a murine T cell clone that recognizes the xenogeneic (human)...
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