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Identification of Key Residues in Dengue Virus NS1 Protein That Are Essential for Its Secretion

30 Apr 2023

Abstract excerpt

Dengue virus (DENV) non-structural protein 1 (NS1) is involved in multiple aspects of the DENV lifecycle. Importantly, it is secreted from infected cells as a hexameric lipoparticle that mediates vascular damage that is a hallmark of severe dengue. Although the secretion of NS1 is known to be important in DENV pathogenesis, the exact molecular features of NS1 that are required for its secretion from cells are not...

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PMID: 37243188
DOI: 10.3390/v15051102

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