Genetic polymorphism and their contribution to cancer susceptibility.

doi:10.1590/s0102-311x1998000700002

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Article

Genetic polymorphism and their contribution to cancer susceptibility.

Cadernos de saude publica - 1 Jan 1998

Conforti-Froes N, el-Zein R, Au W

Abstract excerpt

Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the in...

Topics

Cytochrome P-450 Enzyme System
Environmental Exposure
Enzyme Activation
Genetic Predisposition to Disease
Genotype
Glutathione Transferase
Humans
Neoplasms
Polymorphism, Genetic

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