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Article

Does a betaretrovirus infection trigger primary biliary cirrhosis?

Proceedings of the National Academy of Sciences of the United States of America - 8 Jul 2003

Xu Lizhe, Shen Zhiwei, Guo Linsheng, Fodera Brent, Keogh Adrian, Joplin Ruth, O'Donnell Barbara, Aitken James, Carman William, Neuberger James, Mason Andrew

Abstract excerpt

Patients with primary biliary cirrhosis develop progressive ductopenia associated with the production of antimitochondrial antibodies that react with a protein aberrantly expressed on biliary epithelial cells and peri-hepatic lymph nodes. Although no specific microbe has been identified, it is thought that an infectious agent triggers this autoimmune liver disease in genetically predisposed individuals. Previous...

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Share to Retroviridae Infections
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bile Ducts, Intrahepatic

Share to Fluorescent Antibody Technique, Indirect

Share to Liver Cirrhosis, Biliary

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Source

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Identifiers

PMID: 12832623
DOI: 10.1073/pnas.1433063100
PMCID: PMC166250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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